ClickGUARD's are extremely customizable. You can configure your rules to match a combination of multiple conditions to cover any clicking pattern you would like to react on.
The following rule conditions are available with Advanced Rules:
campaign - apply rules to specific campaign(s)
ad group - apply rules to specific ad group(s)
keyword - apply rules to specific keyword(s)
threat level - apply rules to specific IP threat level(s)
proxy - apply rules only on proxy IPs or non-proxy IPs
device type - apply rules to specific device types (mobile, computer, tablet)
continent - apply rules to specific continent(s)
country - apply rules to specific countries
Click on the condition link to learn more on all the ways you can use the individual rule condition.